biophysical signal monitoring and stimulation techniques

Projects demonstrating this capability:

Hematoma Detector - A Practical Application of Instrumental Motion as Signal in Near Infra-Red Imaging

Functional neuroimaging, particularly functional MRI (fMRI) which provides a measure of regional brain blood flow during behavior, is widely used in the investigation of cognitive processes and has been proposed as a means of evaluating deficits due to traumatic brain injury (TBI) and guiding rehabilitation.

Test setup for prototype hematoma detector system

Image-Based Robotic Targeting System to Control Micromanipulators for Single Cell Studies in Living Biological Tissues

We are developing a second-generation software system for image-based robotic automation of micromanipulators, which entails seamless integration and control of combined optical-mechanical systems used for NINDS biological investigation.

3D model of micromanipulator and micropipette

Non-Injurious Pain Model Using Mice

Patients cite pain as the most common reason for seeking health care, and some medical organizations include pain as a fifth vital sign along with blood pressure, heart rate, temperature, and respirations. While the understanding of the neurophysiologic mechanisms by which noxious and non-noxious stimuli are perceived has substantially improved, the mechanisms of pain are not entirely understood.

Graphic demonstrating Neurometer connection to mouse

PRiME - Physiological Recording in MRI Environment

A multidisciplinary intramural team led by CIT in collaboration with the NHLBI Cardiovascular Intervention Program developed and implemented a fundamental electronics and signal processing tool facilitating MRI catheterization procedure innovation.  As an alternative to surgical techniques in the treatment of cardiovascular disease, NHLBI is developing innovative techniques in cardiovascular catheterization with the use of real-time MRI. The use of MRI greatly reduces the patient’s exposure to ionizing radiation from X-ray imaging, which is typically used in catheterization procedures.

PRiME reduces MRI-induced noise in ECG and IBP signals

System to Measure Rodent Vestibular Sensory Evoked Potentials

The Mouse Auditory Testing Core within NIDCD provides investigators with assistance in testing auditory function in rodents. In addition to the standard auditory testing (such as auditory brainstem response), NIDCD is expanding core capabilities to include the often needed testing of vestibular sensory evoked potentials (VsEPs). VsEPs are used to assess the vestibular system, which is a critical component associated with a sense of balance.

3D model of the custom mouse head clip and mounting hardware for the VsEPs system

Technologies for Neuronal Mapping of Motion Detection and Color Vision Systems of Drosophila

SPIS has been collaborating with NICHD's section on neuronal connectivity and NIBIB to develop one-of-kind virtual-reality (VR) behavioral systems to assess the functions of Drosophila visual circuits. These VR systems are comprised of custom electronics, opto-electronics, imaging systems, mechanical hardware, and software. Since vertebrates share similar visual functions and neural circuit architectures, the research will provide a better understanding of how these systems receive, process, and interpret visual stimuli associated with motion and color.

VR motion detection prototype system

Using Autonomic Responses to Infer Emotional State

Emotions play an important role in decision making. Emotions also influence our autonomic nervous system presumably through the amygdala and other regions of the brain. It has been hypothesized that feedback from autonomic nervous activity enhances learning and decision making. Well-learnt associations are used to predict or anticipate outcomes of related events, thereby increasing the chances of making a correct decision and ultimately increasing the deciding organism’s chances of survival.

Visualization of learning task