scientific programming

Projects demonstrating this capability:

Adaptive Optics Retinal Imaging with Eye Tracking

The goal of this project with the Clinical and Translational Imaging Unit, NEI, is to design and integrate both closed-loop optical stabilization, using real-time retinal tracking, and image registration into an existing adaptive optics scanning light ophthalmoscope to improve image quality and reduce data loss due to eye motion.

Adaptive Optics Kit from Thorlabs

Electron Paramagnetic Resonance (EPR) Imaging of in-vivo Oxygen Status Associated with Cancer Treatment Studies

In this collaboration, EPR imaging technology is demonstrated to be a novel physiological imaging modality useful in obtaining maps of tissue oxygenation quantitatively and non-invasively with high spatial and temporal resolution. In vivo EPR imaging has been successfully implemented in small animal experiments, specifically in mouse models of human cancer to obtain information (e.g., dynamics of tumor physiology, hypoxia) critical for treatment selection (e.g., chemotherapy, anti-angiogenic drug therapy, and radiotherapy) and response monitoring.

EPR imaging system instrumentation

High-resolution Gamma Imager for Small Animal Imaging of Radioisotopes for Cancer Treatment

SPIS collaborated with NCI’s Molecular Imaging Program (MIP) to develop novel imaging systems used in the development of radionuclide-labeled compounds. Successfully developed radionuclide-labeled compounds offer the ultimate prospect of PET, SPECT and planar imaging in human subjects for medical diagnostic and management purposes.  Equally powerful applications exist in basic science when used for probe validation in small laboratory animals.

MONICA detector module and electronics

mHealth Smartphone Application to Measure Risky Driving Behavior and Predict Crashes

The risk of fatal crashes per driven mile is highest among teen drivers compared to other age groups. According to the CDC statistics only in 2014, 221,313 teens drivers were admitted to the emergency department and 2,333 were killed. This amounts to an average of six teen driver deaths every day due to automotive crashes. Improved safety policies are known to reduce the number of motor vehicle crashes among teens.

mHealth Smartphone Application to Measure Risky Driving Behavior

Multiparametric MRI in Localization of Prostate Cancer with Patient-specific MRI-based Prostate Mold Validation

The NCI Molecular Imaging Program develops innovative methods of localizing prostate cancer based on in vivo multiparametric MRI.  SPIS contributes to this effort in two areas.  (1) Assisted in the design, implementation, and validation of individualized MR-based molds to facilitate the correlation of the multiparametric MRI imaging with downstream histopathology.  Achieving sufficient MR/histopathology image correlation (i.e., 3D alignment) is critical when evaluating the efficacy of new prostate imaging protocols as potential cancer diagnostics.  During the initial mold developme

Patient-specific 3D printed Mold

Using Autonomic Responses to Infer Emotional State

Emotions play an important role in decision making. Emotions also influence our autonomic nervous system presumably through the amygdala and other regions of the brain. It has been hypothesized that feedback from autonomic nervous activity enhances learning and decision making. Well-learnt associations are used to predict or anticipate outcomes of related events, thereby increasing the chances of making a correct decision and ultimately increasing the deciding organism’s chances of survival.

Visualization of learning task